Patrick Dempsey, star of Grey’s Anatomy, was chosen Sexiest Man Alive.

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Nearly twenty years have passed since Patrick Dempsey made his small-screen debut on ABC’s Grey’s Anatomy as Doctor Derek “McDreamy” Shepherd. His breakthrough performance as a charming outsider in 1987’s Can’t Buy Me Love was arguably more significant.

His attractiveness sparked a fan obsession so great that he frequently appeared in this magazine over the years. He is now winning the title of Sexiest Man Alive.

In this week’s cover story, the 57-year-old Maine native tells PEOPLE, “I’m glad it’s happening at this point in my life.” “Having the recognition is nice, and it definitely makes my ego feel a little bigger, but it also gives me a platform to use it for good.”

The Dempsey Center, which he established to assist cancer patients and their loved ones in memory of his late mother, holds a special place in his heart.

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